Albiflorin: Overview, Structure, Properties and Formulas

Albiflorin, a well-known Chinese herb, is the main ingredient that has been a significant component of Radix Paeonia Alba used in treating depressive disorders since antiquity. However, the mechanism behind the antidepressant properties of albiflorin isn’t fully understood.

Albiflorin is a monoterpene glycoside that is the primary ingredient of Radix paeoniae Alba that is commonly utilized in herbal remedies across China, Korea, and Japan. Radix paeoniae Alba is often referred to as a peony, the root of Paeonia lactiflora Pall, a part of the family of Ranunculaceae. Buying research chemicals is  ahectic process. But for this purpose many online and trusted stores are available from where you can buy research chemicals.

The root is one of the components of many traditional formulae, such as Jiaweisinisan and Dang Gui Shao Yao San, which are prescribed to treat depression-related disorders. One of these ingredients, Monoterpene glycosides like paeoniflorin and albiflorin, are typically described as the primary active constituents from the peony.

Studies have shown both long- and short-term administration of albiflorin can produce antidepressant-like effects as demonstrated by a decrease in the time of immobility in forced-swim tail-suspension tests on mice and the reverse of the chronic stress-induced mild reduction in sucrose consumption in rats.

Therefore, Albiflorin also produces significant antidepressant effects closely connected to hippocampal 5-HT increases and BDNF expression similar in effect to traditional antidepressant SSRIs. Thats’s why the monoaminergic process and the receptors that albiflorin targets are still unclear.

Albiflorin is a monoterpenoid chemical with the molecular Formula of 23H 28O 11and a molecular weight of 480.46. The molecular structure of Albiflorin is depicted in Formula (I). It is a naturally active substance derived from the root of Paeonia lactillora Pall, Paeonia veitchii Lynch, and P. Suffrsticosa Andrz in Ranuculaceae plants.

Albiflorin has a lactone-ring structure but does not possess a hemiacetal structure. Therefore, it can be converted into two compounds, paeonilactone B and paeonilactone B, in anaerobic conditions.

Recent studies in pharmacology suggest that Albiflorin is analgesic, anticonvulsant, sedative effects, immunosystem-related benefits, smooth-muscle-related effects, anti-inflammatory effects, actions against pathogenic microorganisms, the liver’s protective effects.

In clinical terms, Albiflorin is mainly used to treat treatment of Epilepsia and analgesia and rehabilitation from drug addiction and treatment for vertigo, treatment of arthritis rheumatoid and treating bacillary dysentery as well as enteritis, treatment of viral hepatitis, treatment of age-related illnesses as well as the inability to resist the flocculation of barium sulfate and mucus dissolution. The method used to prepare Albiflorin and its use in the production of the medicinal.


[4-hydroxy-6-methyl-8-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7-oxatricyclo[,9]nonan-9-yl]methyl benzoate



Canonical SMILES


Isomeric SMILES




Property Name Property Value Reference
Molecular Weight 480.5 Computed by PubChem 2.1 (PubChem release 2021.05.07)
XLogP3-AA -1 Computed by XLogP3 3.0 (PubChem release 2021.05.07)
Hydrogen Bond Donor Count 5 Computed by Cactvs (PubChem release 2021.05.07)
Hydrogen Bond Acceptor Count 11 Computed by Cactvs (PubChem release 2021.05.07)
Rotatable Bond Count 7 Computed by Cactvs (PubChem release 2021.05.07)
Exact Mass 480.16316171 Computed by PubChem 2.1 (PubChem release 2021.05.07)
Monoisotopic Mass 480.16316171 Computed by PubChem 2.1 (PubChem release 2021.05.07)
Topological Polar Surface Area 172 Ų Computed by Cactvs (PubChem release 2021.05.07)
Heavy Atom Count 34 Computed by PubChem
Formal Charge 0 Computed by PubChem
Complexity 830 Computed by Cactvs (PubChem release 2021.05.07)
Isotope Atom Count 0 Computed by PubChem
Defined Atom Stereocenter Count 5 Computed by PubChem
Undefined Atom Stereocenter Count 5 Computed by PubChem
Defined Bond Stereocenter Count 0 Computed by PubChem
Undefined Bond Stereocenter Count 0 Computed by PubChem
Covalently-Bonded Unit Count 1 Computed by PubChem
Compound Is Canonicalized Yes Computed by PubChem (release 2021.05.07)






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