Aloe-emodin is a dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It was isolated from plants belonging to the genus Aloe-emodin . It functions as an antineoplastic agent as well as a plant metabolite and also its a dihydroxyanthraquinone and a primary aromatic alcohol. Aloe-emodin comes from a Chrysazin.
About Aloe Emodin
The anthraquinones aloe-emodin and emodin are plentiful in the rhubarb. Numerous lines of evidence suggest that aloe-emodin and emodin possess estrogenic properties as phytoestrogens. However, its effects on the estrogen receptor (ERa) activation and the growth of breast cancer cells are debated. The purpose of this study is to study the effects and molecular mechanisms underlying the aloe-emodin and emodin compounds on the proliferation of breast cancer cells.
Our findings show that both the aloe-emodin and emodin can reduce breast cancer cell proliferative capacity by inhibiting ER and protein levels and thereby inhibiting ER and transcriptional activity. Additionally, treatment with aloe-emodin resulted in the dissociation of the heat shock protein (HSP90) in addition to an increase in ERA and an increase in the rate of A ubiquitination. Even though emodin exhibited similar effects as aloe-emodin but did not promote the HSP90/ER dissociation or the ER ubiquitination. You can research chemicals online. Results from protein fractionation suggest that aloe-emodin could cause cytosolic ER degradation.
Aloe Emodin Concerning
While emodin could trigger the cytosolic ER and degradation, it mainly affected the nuclear ER and distribution that resembles the effect of estrogen when the degradation of proteins was stopped. Our findings show that aloe-emodin and emodin specifically block the growth of breast cancer cells through the targeting of ER and protein stability via different mechanisms. These results suggest the possibility of the use of anthraquinones for preventing the treatment of breast cancers shortly.
Numerous phytochemicals that are derived from plants, like anthraquinone, are believed to have anti-cancer properties. The anthraquinone derivatives emodin (1,3,8-trihydroxy-6-methyl anthraquinone) and aloe-emodin (1,8-dihydroxy-3-hydroxyl-methyl anthraquinone) are the main bioactive components of rhubarb (Rheum palmatum), which has been used in traditional Chinese medicine. Aloe-emodin is also found on the leaves of the widespread species Aloe vera. Emodin has been extensively researched in anti-inflammatory, antibacterial, and antiproliferative actions in various kinds of cancers.
Chemical and Physical properties
|Property Name||Property Value||Reference|
|Molecular Weight||270.24||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|XLogP3-AA||1.8||Computed by XLogP3 3.0 (PubChem release 2021.05.07)|
|Hydrogen Bond Donor Count||3||Computed by Cactvs 18.104.22.168 (PubChem release 2021.05.07)|
|Hydrogen Bond Acceptor Count||5||Computed by Cactvs 22.214.171.124 (PubChem release 2021.05.07)|
|Rotatable Bond Count||1||Computed by Cactvs 126.96.36.199 (PubChem release 2021.05.07)|
|Exact Mass||270.05282342||Computed by PubChem 2.1)|
|Monoisotopic Mass||270.05282342||Computed by PubChem 2.1.07)|
|Topological Polar Surface Area||94.8 Å²||Computed by Cactvs 188.8.131.52)|
|Heavy Atom Count||20||Computed by PubChem|
|Formal Charge||0||Computed by PubChem|
|Complexity||421||Computed by Cactvs 184.108.40.206|
|Isotope Atom Count||0||Computed by PubChem|
|Defined Atom Stereocenter Count||0||Computed by PubChem|
|Undefined Atom Stereocenter Count||0||Computed by PubChem|
|Defined Bond Stereocenter Count||0||Computed by PubChem|
|Undefined Bond Stereocenter Count||0||Computed by PubChem|
|Covalently-Bonded Unit Count||1||Computed by PubChem|
|Compound Is Canonicalized||Yes||Computed by PubChem|
Aloe-Emodin Decrease ER a Protein Levels in a Time- and Dose-Dependent Manner
ER activation is stimulated by estrogen, promoting the development and progression of cancers in the breast. ER is protein levels observed in response to treatment with different dosages of aloe-emodin and emodin (0-100 mm). The results indicate that aloe-emodin and emodin caused a reduction in ER levels. Protein levels in the dose and time-dependent way.
Breast cancer disease is one of the most prevalent cancers in women, and estrogen plays a significant part in the early development of cancer. Estrogen, usually referred to as 17 b-estradiol (E2), binds to its main receptor ER a and induces ER transcriptional activity to regulate the expression of downstream genes and the growth of cells.
Tamoxifen is created to inhibit E2 binding and hinder ER transcriptional activity from treating ER an-dependent conditions like breast cancer. But, alternatives that are more secure and with fewer adverse effects than Tamoxifen have been sought after. Numerous studies show phytoestrogens have an anti-estrogen and estrogenic effect that is specific to the organ. The majority of phytoestrogens are flavones such as Daidzein and genistein and are employed to treat menopausal symptoms and breast cancer.